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DESCRIPTION |
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Tablets and Suspensions |
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Sulfamethoxazole; trimethoprim is a synthetic antibacterial combination
product available in DS (double strength) tablets, tablets and suspensions
for oral administration. Each DS tablet contains 160 mg trimethoprim and 800
mg sulfamethoxazole plus magnesium stearate, pregelatinized starch and
sodium starch glycolate. Each tablet contains 80 mg trimethoprim and 400 mg
sulfamethoxazole plus magnesium stearate, pregelatinized starch, sodium
starch glycolate, FD&C blue no. 1 lake, FD&C yellow no. 6 lake and D&C
yellow no. 10 lake. Each teaspoonful (5 ml) of the pediatric suspension or
suspension contains 40 mg trimethoprim and 200 mg sulfamethoxazole in a
vehicle containing 0.3 percent alcohol, edetate disodium, glycerin,
microcrystalline cellulose, parabens (methyl and propyl), polysorbate 80,
saccharin sodium, simethicone, sorbitol, sucrose, FD&C yellow no. 6, FD&C
red no. 40, flavors and water. |
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Trimethoprim is 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine. It is a
white to light yellow, odorless, bitter compound with a molecular weight of
290.32 and a molecular formula of C14H18N4O3. |
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Sulfamethoxazole is N1-(5-methyl-3-isoxazolyl)
sulfanilamide. It is almost white, odorless, tasteless compound with a
molecular weight of 253.28 and a molecular formula of C10H11N3O3S. |
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IV Infusion |
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Sulfamethoxazole; trimethoprim IV infusion is a sterile solution for
intravenous infusion only, and is a synthetic antibacterial combination
product. Each ml of Septra IV infusion contains 16 mg trimethoprimn and 80
mg sulfamethoxazole compounded with 40% propylene glycol, 10% ethyl alcohol,
and 0.3% diethanolamine; 1% benzyl alcohol and 0.1% sodium metabisulfite
added as preservatives, water for injection, and pH adjusted to
approximately 10 with sodium hydroxide. |
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Trimethoprim is 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamin. It
is a white to light yellow, odorless, bitter compound with a molecular
weight of 290.32 and the molecular formula C14H18N4O3. |
