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DESCRIPTION |
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Each Dyazide capsule for oral use, with opaque red cap and opaque white
body, contains hydrochlorothiazide 25 mg and triamterene 37.5 mg, and is
imprinted with the product name DYAZIDE and SB. Hydrochlorothiazide is a
diuretic/antihypertensive agent and triamterene is an antikaliuretic agent. |
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Hydrochlorothiazide is slightly soluble in water. It is soluble in dilute
ammonia, dilute aqueous sodium hydroxide and dimethylformamide. It is
sparingly soluble in methanol. |
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Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,
2, 4-benzothiadiazine-7-sulfonamide 1,1-dioxide. |
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At 50°C, triamterene is practically insoluble in water (less than 0.1%). It
is soluble in formic acid, sparingly soluble in methoxyethanol and very
slightly soluble in alcohol. |
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Triamterene is 2, 4, 7-triamino-6-phenylpteridine. |
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Inactive ingredients consist of benzyl alcohol, cetylpyridinium chloride,
D&C red no. 33, FD&C yellow no. 6, gelatin, glycine, lactose, magnesium
stearate, microcrystalline cellulose, povidone, polysorbate 80, sodium
starch glycolate, titanium dioxide, and trace amounts of other inactive
ingredients. |
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Dyazide capsules meet Drug Release Test 3 as published in the USP 23
monograph for triamterene and hydrochlorothiazide capsules. |
