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Keflex is a semisynthetic cephalosporin antibiotic intended for oral
administration. It is 7-(D-a-Amino-a-phenylacetamido)-
3-methyl-3-cephem-4-carboxylic acid monohydrate. Cephalexin has the
molecular formula C16H17N3O4S·H2O
and the molecular weight is 365.41. |
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The nucleus of cephalexin is related to that of other cephalosporin
antibiotics. The compound is a zwitterion; i.e.,
the molecule contains both a basic and an acidic group. The
isoelectric point of cephalexin in water is approximately 4.5 to 5. |
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The crystalline form of cephalexin which is available is a
monohydrate. It is a white crystalline solid having a bitter taste.
Solubility in water is low at room temperature; 1 or 2 mg/ml may be
dissolved readily, but higher concentrations are obtained with
increasing difficulty. |
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The cephalosporins differ from penicillins in the structure of the
bicyclic ring system. Cephalexin has a D-phenylglycyl
group as substituent at the 7-amino position and an unsubstituted
methyl group at the 3-position. |
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Each Pulvule contains cephalexin monohydrate equivalent to 250 mg
(720 mcmol) or 500 mg (1,439 mcmol) of cephalexin. The Pulvules also
contain cellulose, Dy & C Yellow No. 10, F Dy & C Blue No. 1, F Dy &
C Yellow No. 6, gelatin, magnesium stearate, silicone, titanium
dioxide, and other inactive ingredients. |
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Each capsule manufactured by Mylan contains cephalexin monohydrate
equivalent to 250 mg (720 mcmol) or 500 mg (1,439 mcmol) of
cephalexin. The capsules also contain cellulose, F Dy & C Blue No.
1, gelatin, magnesium stearate, silicone, titanium dioxide, and
other inactive ingredients. |
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After mixing, each 5 ml of Keflex, for oral suspension, will contain
cephalexin monohydrate equivalent to 125 mg (360 mcmol) or 250 mg
(720 mcmol) of cephalexin. The suspensions also contain flavors,
methylcellulose, silicone, sodium lauryl sulfate, and sucrose. The
125-mg suspension contains F Dy & C Red No. 40, and the 250-mg
suspension contains F Dy & C Yellow No. 6. |
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Each capsule manufactured by Biocraft contains cephalexin
monohydrate equivalent to 250 mg (720 mcmol) or 500 mg (1,439 mcmol)
of cephalexin. Inactive ingredients: magnesium stearate, silicone
dioxide and may contain talc. Capsul shell and print constituents:
black iron oxide, Dy & C Yellow #10 aluminium lake, FD & C blue #1
aluminium lake, FD & C Blue #2 aluminium lake, FD & C Red #40
aluminium lake, gelatin, pharmaceutical glaze modified in SD-45,
silcon dioxide or carbomethylcellulose sodium, sodium lauryl
sulfate, titanium dioxide and may contian propylene glyceryl. In
addition, the 250 mg capsule shell contains yellow iron oxide. |
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Each tablet manufactured by Biocraft contains cephalexin monohydrate
equivalent to 250 mg (720 mcmol) or 500 mg (1,439 mcmol) of
cephalexin. Inactive ingredients: hydroxypropyl methylcellulose,
magnesium stearate, microcrystalline cellulose, polyethylene glycol,
polysorbate 90, sodium starch glycolate and titanium dioxide. |
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Metformin HCl is a white to off-white crystalline compound with a
molecular formula of C4H11N5•HCl
and a molecular weight of 165.63. Metformin HCl is freely soluble in
water and is practically insoluble in acetone, ether and chloroform. The
pKa of
metformin is 12.4. The pH of a 1% aqueous solution of metformin HCl is
6.68. |
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Metformin HCl tablets contain 500 mg and 850 mg of metformin HCl. In
addition, each tablet contains the following inactive ingredients:
povidone, magnesium stearate and hydroxypropyl methylcellulose (hypromellose)
coating. |
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