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Zithromax (azithromycin tablets, azithromycin capsules and azithromycin
for oral suspension) contain the active ingredient azithromycin, an
azalide, a subclass of macrolide antibiotics, for oral administration.
Azithromycin has the chemical name (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one.
Azithromycin is derived from erythromycin; however, it differs
chemically from erythromycin in that a methyl-substituted nitrogen atom
is incorporated into the lactone ring. Its molecular formula is C38H72N2O12,
and its molecular weight is 749.00. |
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Azithromycin, as the dihydrate, is a white crystalline powder with a
molecular formula of C38H72N2O12•2H2O
and a molecular weight of 785.0. |
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Zithromax is supplied for oral administration as film-coated, modified
capsular shaped tablets containing azithromycin dihydrate equivalent to
250 mg azithromycin and the following inactive ingredients: dibasic
calcium phosphate anhydrous, pregelatinized starch, sodium
croscarmellose, magnesium stearate, sodium lauryl sulfate, hydroxypropyl
methylcellulose, lactose, titanium dioxide, triacetin and D&C red #30
aluminum lake. |
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Zithromax capsules contain azithromycin dihydrate equivalent to 250 mg
of azithromycin. The capsules are supplied in red opaque hard-gelatin
capsules (containing FD&C red #40). They also contain the following
inactive ingredients: anhydrous lactose, corn starch, magnesium stearate,
and sodium lauryl sulfate. |
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It is also supplied as a powder for oral suspension. |
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Zithromax for oral suspension is supplied in bottles containing
azithromycin dihydrate powder equivalent to 300 mg, 600 mg, 900 mg, or
1200 mg azithromycin per bottle and the following inactive ingredients:
sucrose; sodium phosphate; tribasic; anhydrous; hydroxypropyl cellulose;
xanthan gum; FD&C red #40; and spray dried artificial cherry, creme de
vanilla and banana flavors. After constitution, each 5 ml of suspension
contains 100 mg or 200 mg of azithromycin. |
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