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DESCRIPTION |
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Augmentin is an oral antibacterial combination consisting of the
semisynthetic antibiotic amoxicillin and the b-lactamase
inhibitor, clavulanate potassium (the potassium salt of clavulanic acid).
Amoxicillin is an analog of ampicillin, derived from the basic penicillin
nucleus, 6-aminopenicillanic acid. The amoxicillin molecular formula is C16H19N3O5S·3H2O
and the molecular weight is 419.46. Chemically, amoxicillin is
(2S, 5R, 6R)-6-[(R)-(-)-2-Amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic
acid trihydrate. |
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Clavulanic acid is produced by the fermentation of Streptomyces clavuligerus.
It is a b-lactam structurally
related to the penicillins and possesses the ability to inactivate a wide
variety of b-lactamases
by blocking the active sites of these enzymes. Clavulanic acid is
particularly active against the clinically important plasmid mediated
b-lactamases frequently
responsible for transferred drug resistance to penicillins and
cephalosporins. The clavulanate potassium molecular formula is C8H8KNO5
and the molecular weight is 237.25. Chemically clavulanate potassium is
potassium (Z)-(2R,5R )-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]-heptane-2-carboxylate. |
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Each Augmentin tablet contains 0.63 mEq potassium. |
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Each 125 mg chewable tablet and each 5 ml of reconstituted Augmentin 125
mg/5 ml oral suspension contains 0.16 mEq potassium. Each 250 mg chewable
tablet and each 5 ml of reconstituted Augmentin 250 mg/5 ml oral suspension
contains 0.32 mEq potassium. Each 200 mg chewable tablet and each 5 ml of
reconstituted Augmentin 200 mg/5 ml oral suspension contains 0.14 mEq
potassium. Each 400 mg chewable tablet and each 5 ml of reconstituted
Augmentin 400 mg/5 ml oral suspension contains 0.29 mEq of potassium. |
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Inactive Ingredients |
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Powder for Oral Suspension: Colloidal silicon
dioxide, flavorings, succinic acid, xanthan gum, and one or more of the
following: aspartame, hydroxypropyl methylcellulose, mannitol, silica gel,
silicon dioxide and sodium saccharin. |
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Chewable Tablets: Colloidal silicon dioxide,
flavorings, magnesium stearate, mannitol and one or more
of the following: aspartame, D&C yellow no. 10, FD&C red no. 40, glycine,
sodium saccharin and succinic acid. |
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Tablets: Colloidal silicon dioxide, hydroxypropyl
methylcellulose, magnesium stearate, microcrystalline cellulose,
polyethylene glycol, sodium starch glycolate and titanium dioxide. |
