Conjugated estrogens is a mixture of estrogens, obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares' urine. It contains estrone, equilin, and 17 a-dihydroequilin, together with smaller amounts of 17 a-estradiol, equilenin, and 17 a-dihydroequilenin as salts of their sulfate esters.

Tablets

Tablets for oral administration are available in 0.3 mg, 0.625 mg, 0.9 mg, 1.25 mg, and 2.5 mg strengths of conjugated estrogens.

Premarin Tablets Contain the Following Inactive Ingredients: Calcium phosphate tribasic, calcium sulfate anhydrous (white tablet), calcium sulfate, carnauba wax, cellulose, glyceryl monooleate, lactose, magnesium stearate, methylcellulose, pharmaceutical glaze, polyethylene glycol, stearic acid, sucrose, talc, titanium dioxide. 0.3 mg Tablets Also Contain: D&C yellow no. 10, FD&C blue no. 1, FD&C blue no. 2, FD&C yellow no. 6. 0.625 mg Tablets Also Contain: FD&C blue no. 2, D&C red no. 27, FD&C red no. 40. 0.9 mg Tablets Also Contain: D&C red no. 6, D&C red no. 7. 1.25 mg Tablets Also Contain: Black iron oxide, D&C yellow no. 10, FD&C yellow no. 6. 2.5 mg Tablets Also Contain: FD&C blue no. 2, D&C red no. 7.

Injection

Each Secule vial contains 25 mg of conjugated estrogens, in a sterile lyophilized cake which also contains lactose 200 mg, sodium citrate 12.2 mg, and simethicone 0.2 mg. The pH is adjusted with sodium hydroxide or hydrochloric acid. A sterile diluent (5 ml) containing 2% benzyl alcohol in sterile water is provided for reconstitution. The reconstituted solution is suitable for intravenous or intramuscular injection.

Vaginal Cream

Each gram of Premarin vaginal cream contains 0.625 mg conjugated estrogens, in a nonliquefying base containing cetyl esters wax, cetyl alcohol, white wax, glyceryl monostearate, propylene glycol monostearate, methyl stearate, benzyl alcohol, sodium lauryl sulfate, glycerin, and mineral oil. Premarin vaginal cream is applied intravaginally.