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CATEGORIES: Hypercholesterolemia; Hyperlipidemia; Hyperproteinemia; Dysbetalipoproteinemia, primary; Pregnancy Category X
Drug Classes: Hyperlipidemia
BRAND NAMES: Lipitor; Sortis; Tahor
Atorvastatin calcium is a synthetic lipid-lowering agent. Atorvastatin is an inhibitor of 3 hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis.
Atorvastatin calcium is [R-(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4 [(phenylamino)carbonyl]-lH-pyrrole-1-heptanoic acid, calcium salt (2:1) trihydrate. The empirical formula of atorvastatin calcium is (C33H34FN2O5)2Ca·3H2O and its molecular weight is 1209.42.
Atorvastatin calcium is a white to off-white crystalline powder that is insoluble in aqueous solutions of pH 4 and below. Atorvastatin calcium is very slightly soluble in distilled water, pH 7.4 phosphate buffer, and acetonitrile, slightly soluble in ethanol, and freely soluble in methanol.
Lipitor tablets for oral administration contain 10, 20, or 40 mg atorvastatin and the following inactive ingredients: calcium carbonate, candelilla wax, croscarmellose sodium, hydroxypropyl cellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, opadry white YS-1-7040 (hydroxypropylmethylcellulose, polyethylene glycol, talc, titanium dioxide); polysorbate 80, simethicone emulsion.
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