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CATEGORIES: Angina pectoris; Hypertension, essential; Infarction, myocardial; Pregnancy Category C Drugs; WHO Formulary
Drug Classes: Antianginals; Antihypertensives; Beta Blockers
BRAND NAMES: Alinor; Altol;
Anselol; Antipressan; Apo-Atenolol; Atcardil;
Atecard; AteHexal; Atelol; Atenblock; Atendol;
Atenet; Ateni; Atenil; Atenol; Atereal;
Aterol; Atolmin; Betablok; Betacard; Blokium; B-Vasc;
Catenol; Coratol; Corotenol; Evitocor; Farnormin;
Felo-Bits; Hypoten; Hipres; Internolol; Lo-ten;
Loten; Lotenal; Myocord; Normalol; Normiten;
Noten; Oraday; Premorine; Prenolol; Seles; Serten;
Stermin; Tenidon; Tenoblock; Tenolin; Tenolol;
Tenoprin; Tenormin; Tenormine; Tensig; Tensimin; Tredol;
Urosin; Vascoten; Vericordin; Wesipin; Xaten
(Foreign Brand names outside U.S. in italics)
Atenolol, a synthetic, beta1-selective (cardioselective) adrenoreceptor blocking agent, may be chemically described as benzeneacetamide, 4 -[2'-hydroxy-3'-[(1- methylethyl) amino] propoxy]-.
Atenolol (free base) has a molecular weight of 266. It is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/ml at 37°C and a log partition coefficient (octanol/water) of 0.23. It is freely soluble in 1N HCl (300 mg/ml at 25°C) and less soluble in chloroform (3 mg/ml at 25°C).
Tablets
Tenormin is available as 25, 50 and 100 mg tablets for oral administration.
Tenormin Inactive Ingredients: Magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate.
IV Injection
Atenolol for parenteral administration contains 5 mg atenolol in 10 ml sterile, isotonic, citrate-buffered, aqueous solution. The pH of the solution is 5.5-6.5.
Tenormin Inactive Ingredients: Sodium chloride for isotonicity and citric acid and sodium hydroxide to adjust pH.
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