Amlodipine Besylate

CATEGORIES, DRUG CLASSES, BRAND NAMES

CATEGORIES: Angina, chronic stable; Angina, variant; Hypertension, essential; Pregnancy Category C; FDA Class 1S ("Standard Review")

Drug Classes: Antihypertensives; Calcium Channel Blockers

BRAND NAMES: Amcard; Amdepin; Amdipin; Amlodin; Amlopin; Amlor; Amlosyn; Calchek; Istin; Norvas; Norvasc; Norvask; Tensivask
(Foreign Brand names outside U.S. in italics)

DESCRIPTION

Amlodipine besylate is a long-acting calcium channel blocker.

Amlodipine besylate is chemically described as (R.S.) 3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate benzenesulphonate. Its empirical formula is: C₂₀H₂₅ClN₂O₅·C₆H₆O₃S.

Amlodipine besylate is a white crystalline powder with a molecular weight of 567.1. It is slightly soluble in water and sparingly soluble in ethanol. Amlodipine besylate tablets are formulated as white tablets equivalent to 2.5, 5 and 10 mg of amlodipine for oral administration. In addition to the active ingredient, amlodipine besylate, each tablet contains the following inactive ingredients: microcrystalline cellulose, dibasic calcium phosphate anhydrous, sodium starch glycolate, and magnesium stearate.